The potential of mitochondrial modulation by neuroglobin in treatment of neurological disorders

Neuroglobin is the third member of globin family to be identified in 2000 neurons both human and mouse nervous systems. an oxygen-binding found within central system as well peripheral neurons, that produces a protective effect against hypoxic/ischemic damage induced by promoting oxygen availability mitochondria. Numerous investigations have demonstrated impaired neuroglobin functioning implicated pathogenesis multiple neurodegenerative disorders. Several vitro animal studies reported potential upregulation improving neuroprotection through modulation mitochondrial functions, such ATP production, clearing reactive species (ROS), dynamics mitochondria, controlling apoptosis. acts stress-inducible globin, which has been associated insults where it protect heart brain, providing wide range applicability treatment This review article discusses normal physiological functions mitochondria-associated pathways, outlining how dysregulation with